The IT landscape at mid-to-large health organizations is dominated by electronic health record systems (EHR), a market led by Cerner, EPIC and Meditech. Innovative applications to support health care (addressing COVID, other CRISPR DNA therapies/research and so much more) are available on Amazon Web Services (AWS), Azure and Google Cloud platforms. The eWISE AgileHealth© approach enables secure access to data, appropriate integration of new data and enables integration to the millions of health devices (and providing vendors) that are modern health care. Are you ready to visit the 3-Domain Architecture?